1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide tetrafluoroborate
2-(7-Azabenzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate
CAS: 873798-09-5
Molecular Formula: C10H15BF4N6O
1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide tetrafluoroborate - Names and Identifiers
| Name | 2-(7-Azabenzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate |
| Synonyms | TATU 2-(7-Azabenzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate O-(7-Azabenzotriazole-1-yl)-N,N,N',N'-tetraMethyluroniuM tetrafluoroborat O-(7-Azabenzotriazole-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate TATU (O-(7-AZABENZOTRIAZOL-1-YL)-N,N,N'',N''-TETRAMETHYLURONIUM TETRAFLUOROBORATE) 2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide tetrafluoroborate [bis(dimethylamino)methylidene](3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)oxonium tetrafluoroborate |
| CAS | 873798-09-5 |
| EINECS | 805-247-5 |
| InChI | InChI=1/C10H15N6O.BF4/c1-14(2)10(15(3)4)17-16-9-8(12-13-16)6-5-7-11-9;2-1(3,4)5/h5-7H,1-4H3;/q+1;-1 |
1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide tetrafluoroborate - Physico-chemical Properties
| Molecular Formula | C10H15BF4N6O |
| Molar Mass | 322.07 |
| Melting Point | 184 °C(dec.) |
| Appearance | White powder |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide tetrafluoroborate - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R65 - Harmful: May cause lung damage if swallowed |
| Safety Description | S20 - When using, do not eat or drink. S22 - Do not breathe dust. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | 1759 |
| HS Code | 29339990 |
| Hazard Class | 8 |
| Packing Group | III |
1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide tetrafluoroborate - Introduction
2-(7-Azabenzotriazole-1-yl)-1,1,3,3-tetramethyl tetrafluoroborate, commonly abbreviated as TBTU, is an organic compound. The following is a description of some of the properties, uses, formulation and safety information of TBTU:
Nature:
TBTU is a colorless crystalline solid and is a commonly used activator in chemical reactions. It is stable at room temperature, soluble in organic solvents such as dimethylthionamide (DMSO) and N,N-dimethylacetamide (DMF), but almost insoluble in water.
Use:
TBTU is commonly used as an activator of amino acids and polypeptides to promote acylation reactions. TBTU can effectively introduce amino acids or amino groups when synthesizing peptide chains or other organic compounds. It has a wide range of applications in solid phase synthesis and liquid phase synthesis.
Preparation Method:
The preparation of TBTU usually involves the following steps:
1. Reaction with tetramethylurea: tetramethylurea is reacted with trifluoroboric acid to obtain tetramethylurea tetrafluoroborate.
2. reaction with 7-azabenzotriazole: tetramethylurea tetrafluoroborate reacts with 7-azabenzotriazole to generate TBTU.
Safety Information:
TBTU is relatively stable under normal conditions, but contact with skin and eyes should still be avoided. Wear appropriate protective gloves and goggles during operation. The operation needs to be carried out in a well-ventilated area to prevent inhalation and swallowing. If inhaled or taken by mistake, seek medical attention immediately.
Nature:
TBTU is a colorless crystalline solid and is a commonly used activator in chemical reactions. It is stable at room temperature, soluble in organic solvents such as dimethylthionamide (DMSO) and N,N-dimethylacetamide (DMF), but almost insoluble in water.
Use:
TBTU is commonly used as an activator of amino acids and polypeptides to promote acylation reactions. TBTU can effectively introduce amino acids or amino groups when synthesizing peptide chains or other organic compounds. It has a wide range of applications in solid phase synthesis and liquid phase synthesis.
Preparation Method:
The preparation of TBTU usually involves the following steps:
1. Reaction with tetramethylurea: tetramethylurea is reacted with trifluoroboric acid to obtain tetramethylurea tetrafluoroborate.
2. reaction with 7-azabenzotriazole: tetramethylurea tetrafluoroborate reacts with 7-azabenzotriazole to generate TBTU.
Safety Information:
TBTU is relatively stable under normal conditions, but contact with skin and eyes should still be avoided. Wear appropriate protective gloves and goggles during operation. The operation needs to be carried out in a well-ventilated area to prevent inhalation and swallowing. If inhaled or taken by mistake, seek medical attention immediately.
Last Update：2024-04-09 02:00:48
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Product Name: O-(7-Azabenzotriazole-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate Visit Supplier Webpage Request for quotation
CAS: 873798-09-5
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 873798-09-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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